apalutamide will lower the extent or impact of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Stay away from or Use Alternate Drug. Coadministration of apalutamide, a solid CYP2C19 inducer, with drugs that happen to be CYP2C19 substrates can result in lessen publicity to these prescription drugs.
iloperidone improves levels of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Iloperidone is often a time-dependent CYP3A inhibitor and will lead to increased plasma amounts of drugs predominantly removed by CYP3A4.
Use Warning/Monitor. Ethinyl estradiol may possibly inhibit the clearance of benzodiazepines that undergo oxidation, therefore growing serum concentrations of concomitantly administered benzodiazepines.
The above facts is delivered for normal informational and educational applications only. Particular person programs may possibly range and formulary information and facts modifications. Speak to the relevant program supplier for the most existing data.
quinupristin/dalfopristin will increase the stage or outcome of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
lumefantrine will decrease the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Antegrade amnesia could arise working with therapeutic dosages, the risk escalating at bigger dosages; amnestic results could be linked to inappropriate actions
withdrawal reactions, which include seizures, get more info which can be life-threatening; use gradual taper when discontinuing therapy to cut back withdrawal reactions threat
A call to prescribe diazepam rectal gel will involve more than the analysis and selection of proper dose
VALTOCO can be a prescription drugs used for the quick-expression remedy of seizure clusters (often known as “episodes of Repeated seizure exercise” or “acute repetitive seizures”) in people 6 a long time of age and older.
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istradefylline will raise the stage or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
lasmiditan, diazepam. Either improves results of one other by sedation. Use Warning/Keep an eye on. Coadministration of lasmiditan and also other CNS depressant medicines, together with Alcoholic beverages haven't been evaluated in scientific experiments. Lasmiditan could bring about sedation, in addition to other cognitive and/or neuropsychiatric adverse reactions.
eslicarbazepine acetate will lower the extent or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.